When a tornado touches down in Atlanta with Chastain directly in its path, the entire staff goes into crisis mode. Conrad and Nic work on an injured EMT and Devon and Leela become trapped with a man who has severe head trauma, causing them to operate with limited medical supplies. Meanwhile, Bell pulls The Raptor and Dr. Wong onto a case involving a young cancer patient in need of a very risky surgery and Cain gets assigned a new resident.