The story takes place in Hemlock Grove, a fictional town in Pennsylvania. The city is a mixture of extreme wealth and poverty lucie, as a result of the sudden closure of the steel plant. The city’s main sources of jobs are now Hemlock Acres Hospital and Godfrey Institute of Biomedical Technologies. Led by the powerful Godfrey Family, The Institute is shrouded in various rumors of sinister experiments. The macabre mill of the city turns into an even more sinister mystery when two teenage girls are brutally murdered, their bodies being specially left to be found the next day by locals. Peter Rumancek, a 17-year-old rumored to be a werewolf, ends up being suspected of these heinous crimes. To prove his innocence, Peter, along with Roman, the heir to the Godfrey estate, set out on a journey to unravel the mysteries that lurk in Hemlock Grove.